Project leader:
Group leader:
|
Prof. Thomas Bley
Dr. Juliane Steingroewer
|
Agenda:
The aim of
the project is to develop biotechnological processes for the
production of secondary metabolites with plant cell and
tissue cultures as well as a product-specific downstream
processing based on different model systems. In order that,
the technical basis for GMP-compliant solutions (Good
Manufacturing Practice) for the use in the wood products
industry (fungicidal coatings), food (colourings and
flavourings), pharmaceutical and cosmetic industries (drugs)
is provided. As a part of the research a technology platform
is built, on which basis new innovative processes can be
transferred into the economy.
Fig. 1: Bubble column w. Hairy roots of B.
vulgaris
|
Fig. 2: Stirred tank reactor with suspension culture of
Helianthus annuus
|
Fig. 3: Bubble column with Hairy roots of
Harpagophytum procumbens
Fig. 4: Agar plate with Hairy roots of Beta
vulgaris (beetroot)
|
(Figures 1
to 4 are taken from former projects of the Institute of Food
Technology and Bioprocess Engineering.)
By the use
of transformed and untransformed cells of Salvia spp.
(sage), Helianthus annuus (sunflower) and Symphytum
officinale (comfrey) the production of secondary
metabolites has to be analysed and optimised. Furthermore,
the generation, screening and analyses of the callus- and
Hairy root cultures as well as the produced metabolites and
the process of up scaling are main parts of the project.
Although
White Biotechnology applications have considerable
advantages, the industrial application is still
underachieved. The project's objective is to identify the
hurdles and to present possible solutions. The technique's
profitability and environmental effect will be researched on
one exemplary technique of White Biotechnology. For this
reason the production process will be modelled and analysed
with classic tools of business studies and environmental
performance concepts with the objective to identify
significant variables for an ecological and economical
improvement.
The further
objective is to create a competent, highly motivated group of
young scientists (see the picture below). To ensure that
well-trained and educated academic researchers remain in
Saxony and innovative scientific and economic projects in the
field of White Biotechnology are established.
Fig. 5: Members of the interdisciplinary group of junior
scientists "White biotechnology with plant cells“
f.l.t.r.: Christiane Haas, Maria Lisa Socher, Joachim
Püschel, Dr. Juliane Steingroewer, Annemarie Lippert,
Anne-Karen Hüske, Sibylle Schulz, Kristin Halbauer, Jan
Endrikat, Katja Geipel, Felix Lenk, Felix Krujatz and
Hubertus Delenk // photo: TUD/MZ/MD/LIEBERT
Project staff:
(according to the
chair)
Chair of Bioprocess
Engineering, Institute of Food Technology and
Bioprocess Engineering, Faculty of Mechanical
Engineering
Scientists/
Project staff |
Research focus |
Contact data |
Dipl.-Ing.
Katja Geipel
(Bioprocess Engineer)
|
- α-tocopherol-production with
Helianthus annuus
- Optimization in terms of bioprocess
engineering
|
Tel.: +49-(0)351-463 39042
 Katja.Geipel(at)tu-dresden.de |
Dipl.-LMC
Sibylle Schulz
(Food Chemist)
|
- Development of methods for determination of
characteristic metabolites
- Monitoring for production of
metabolites
- of Hairy root
cultures
|
Tel.: +49-(0)351-463 39042
Sibylle.Schulz(at)tu-dresden.de |
Dipl.-Ing.
Felix Lenk
(Electrical Engineer)
|
- Modelling of cell growth of callus- and Hairy root
cultures
- Optimization of the production
of plant secondary metabolites
|
Tel.: +49-(0)351-463 33386
Felix.Lenk(at)tu-dresden.de |
M.Sc.
Felix Krujatz
(Bioprocess Engineer)
|
- Optimization of plant cell production in
bioreactors
- Optimization of the production
of plant secondary metabolites
|
Tel.: +49-(0)351-463 36943
Felix.Krujatz(at)tu-dresden.de |
VMTA
Kristin Halbauer |
Lab assistant |
Tel.: +49-(0)351-463 35566
Kristin.Halbauer(at)
tu-dresden.de |
Chair of Plant Physiology, Institute
of Botany, Department of Biology, Faculty of Mathematics
and Natural Sciences
| Scientists |
Research focus |
Contact data |
Dipl.-Pharm.
Annemarie Lippert
(Pharmacist)
|
- Extraction of metabolites from Hairy root cultures
of Symphytum
officinale
- Elimination of biosynthesis of pyrrolizidine
alkaloids
|
Tel.: +49-(0)351-463 31989
Annemarie.Lippert(at)
mailbox.tu-dresden.de |
Dipl.-Biol.
Joachim Püschel
(Biologist)
|
- Generation of transgenic Helianthus annuus to
increase α-tocopherol synthesis
- Characterisation and quantification of accumulated
secondary metabolites
|
Tel.: +49-(0)351-463 39550
Joachim.Pueschel(at)
mailbox.tu-dresden.de |
Chair of Business Administration,
especially Environmental Management and Accounting,
Faculty of Business and Economics
Prof. André Wagenführ
Tel.: +49-(0)351-463 38101
Sabine.Sickert(at)tu-dresden.de
| Scientist |
Research focus |
Contact data |
Hubertus Delenk
|
Establishment of the application
of fungicidal products on wooden materials |
Tel.: +49-(0)351-463 38322
Hubertus.Delenk(at)
tu-dresden.de |
Press comments:
To the Downloadpage
of our research group.
Project funding:
- European Social Funds
- the Free State of Saxony
| Project number: |
080938406 |
| Project term: |
01.10.2009 - 30.09.2012 |
| Contact details: |
Steingroewer,
Bley
|
